PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB

NADPH oxidases are a major source of superoxide production in the vasculature. The constitutively active Nox4 subunit, which is selectively upregulated in the lungs of human subjects and experimental animals with pulmonary hypertension, is highly expressed in vascular wall cells. We demonstrated tha...

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Main Authors: Lu, Xianghuai, Murphy, Tamara C., Nanes, Mark S., Hart, C. Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957423/
https://ncbi.nlm.nih.gov/pubmed/20622120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00090.2010
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