A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

The mouse Period2 (mPer2) locus is an essential negative-feedback element of the mammalian circadian-clock mechanism. Recent work has shown that mPer2 circadian gene expression persists in both central and peripheral tissues. Here, we analyze the mouse mPer2 promoter and identify a circadian enhance...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Yoo, Seung-Hee, Ko, Caroline H., Lowrey, Phillip L., Buhr, Ethan D., Song, Eun-joo, Chang, Suhwan, Yoo, Ook Joon, Yamazaki, Shin, Lee, Choogon, Takahashi, Joseph S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548324/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15699353/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409763102
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