Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation

We previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the Per2 3′-UTR region: Per2::Luc, which retains the endogenous Per2 3′-UTR and Per2::LucSV, where the endogenous Per2 3′-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yoo, Seung-Hee, Kojima, Shihoko, Shimomura, Kazuhiro, Koike, Nobuya, Buhr, Ethan D., Furukawa, Tadashi, Ko, Caroline H., Gloston, Gabrielle, Ayoub, Christopher, Nohara, Kazunari, Reyes, Bryan A., Tsuchiya, Yoshiki, Yoo, Ook-Joon, Yagita, Kazuhiro, Lee, Choogon, Chen, Zheng, Yamazaki, Shin, Green, Carla B., Takahashi, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651750/
https://ncbi.nlm.nih.gov/pubmed/28973913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706611114
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