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Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock(Δ19/+) mice contributes to improved glucose homeostasis
Circadian clocks orchestrate essential physiology in response to various cues, yet their mechanistic and functional plasticity remains unclear. Here, we investigated Clock(Δ19/+) heterozygous (Clk/+) mice, known to display lengthened periodicity and dampened amplitude, as a model of partially pertur...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4521189/ https://ncbi.nlm.nih.gov/pubmed/26228022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12801 |
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