Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock(Δ19/+) mice contributes to improved glucose homeostasis

Circadian clocks orchestrate essential physiology in response to various cues, yet their mechanistic and functional plasticity remains unclear. Here, we investigated Clock(Δ19/+) heterozygous (Clk/+) mice, known to display lengthened periodicity and dampened amplitude, as a model of partially pertur...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Autores principales: Jeong, Kwon, He, Baokun, Nohara, Kazunari, Park, Noheon, Shin, Youngmin, Kim, Seonghwa, Shimomura, Kazuhiro, Koike, Nobuya, Yoo, Seung-Hee, Chen, Zheng
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521189/
https://ncbi.nlm.nih.gov/pubmed/26228022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12801
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares