Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluc...

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Detalhes bibliográficos
Main Authors: Ko, Caroline H., Yamada, Yujiro R., Welsh, David K., Buhr, Ethan D., Liu, Andrew C., Zhang, Eric E., Ralph, Martin R., Kay, Steve A., Forger, Daniel B., Takahashi, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953532/
https://ncbi.nlm.nih.gov/pubmed/20967239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000513
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