The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude

The mouse Clock gene encodes a basic helix–loop–helix-PAS transcription factor, CLOCK, that acts in concert with BMAL1 to form the positive elements of the circadian clock mechanism in mammals. The original Clock mutant allele is a dominant negative (antimorphic) mutation that deletes exon 19 and ca...

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Main Authors: Vitaterna, Martha Hotz, Ko, Caroline H., Chang, Anne-Marie, Buhr, Ethan D., Fruechte, Ethan M., Schook, Andrew, Antoch, Marina P., Turek, Fred W., Takahashi, Joseph S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474012/
https://ncbi.nlm.nih.gov/pubmed/16754844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603601103
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