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Circadian mutant Overtime reveals F-box protein FBXL3 regulation of Cryptochrome and Period gene expression
Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (~26 h) circadian mutant named Overtime (Ovtm). Positional cloning and genetic complementation reveal that Ovtm is encoded by the F-box protein FBXL3 a co...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3762874/ https://ncbi.nlm.nih.gov/pubmed/17462724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.04.030 |
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