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Circadian mutant Overtime reveals F-box protein FBXL3 regulation of Cryptochrome and Period gene expression

Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (~26 h) circadian mutant named Overtime (Ovtm). Positional cloning and genetic complementation reveal that Ovtm is encoded by the F-box protein FBXL3 a co...

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Detalhes bibliográficos
Main Authors: Siepka, Sandra M., Yoo, Seung-Hee, Park, Junghea, Song, Weimin, Kumar, Vivek, Hu, Yinin, Lee, Choogon, Takahashi, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762874/
https://ncbi.nlm.nih.gov/pubmed/17462724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.04.030
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