miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis

Drug resistance, which is closely correlated with an imbalance in apoptosis, endows colorectal cancer (CRC) with enhanced progression capacity irrespective of the treatment with therapeutics. We report that miR-15b-5p is a tumor suppressor whose level is globally decreased in CRC cells and tissues....

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhao, Ci, Zhao, Qi, Zhang, Chunhui, Wang, Guangyu, Yao, Yuanfei, Huang, Xiaoyi, Zhan, Fei, Zhu, Yuanyuan, Shi, Jiaqi, Chen, Jianan, Yan, Feihu, Zhang, Yanqiao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482850/
https://ncbi.nlm.nih.gov/pubmed/28646148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04172-z
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