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Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
During bone remodelling, osteoclasts induce chemotaxis of osteoblasts and yet maintain spatial segregation. We show that osteoclasts express the repulsive guidance factor Semaphorin 4D and induce contact inhibition of locomotion (CIL) in osteoblasts through its receptor Plexin-B1. To examine causali...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5482063/ https://ncbi.nlm.nih.gov/pubmed/28635959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15831 |
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