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Prostaglandin-mediated inhibition of PTH-stimulated β-catenin signaling in osteoblasts by bone marrow macrophages

Bone marrow macrophages (BMMs), in the presence of cyclooxygenase-2 (Cox2) produced PGE(2), secrete an inhibitory factor in response to Rankl that blocks PTH-stimulated osteoblastic differentiation. This study was to determine if the inhibitory factor also blocks PTH-stimulated Wnt signaling. Primar...

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Bibliographic Details
Published in:Bone
Main Authors: Estus, Thomas L., Choudhary, Shilpa, Pilbeam, Carol C.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835216/
https://ncbi.nlm.nih.gov/pubmed/26851123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2016.01.023
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