Prostaglandin E(2) acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro

Intermittent PTH is the major anabolic therapy for osteoporosis while continuous PTH causes bone loss. PTH acts on the osteoblast (OB) lineage to regulate bone resorption and formation. PTH also induces cyclooxygenase-2 (COX-2), producing prostaglandin E(2) (PGE(2)) that can act on both OBs and oste...

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Hauptverfasser: Choudhary, Shilpa, Blackwell, Katherine, Voznesensky, Olga, Roy, Abhijit Deb, Pilbeam, Carol
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073290/
https://ncbi.nlm.nih.gov/pubmed/23639875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.04.017
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