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Prostaglandin E(2) acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro
Intermittent PTH is the major anabolic therapy for osteoporosis while continuous PTH causes bone loss. PTH acts on the osteoblast (OB) lineage to regulate bone resorption and formation. PTH also induces cyclooxygenase-2 (COX-2), producing prostaglandin E(2) (PGE(2)) that can act on both OBs and oste...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4073290/ https://ncbi.nlm.nih.gov/pubmed/23639875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.04.017 |
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