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Prostaglandin E(2) acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro
Intermittent PTH is the major anabolic therapy for osteoporosis while continuous PTH causes bone loss. PTH acts on the osteoblast (OB) lineage to regulate bone resorption and formation. PTH also induces cyclooxygenase-2 (COX-2), producing prostaglandin E(2) (PGE(2)) that can act on both OBs and oste...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4073290/ https://ncbi.nlm.nih.gov/pubmed/23639875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.04.017 |
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