Factors influencing biased agonism in recombinant cells expressing the human α(1A)‐adrenoceptor

BACKGROUND AND PURPOSE: Agonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β‐arrestins. Since the demonstration of biased agonism has implications for drug discovery, it is essential to consider confounding factors contributing to bias. We have examined bias...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: da Silva Junior, Edilson Dantas, Sato, Masaaki, Merlin, Jon, Broxton, Natalie, Hutchinson, Dana S, Ventura, Sabatino, Evans, Bronwyn A, Summers, Roger J
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481649/
https://ncbi.nlm.nih.gov/pubmed/28444738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13837
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares