Factors influencing biased agonism in recombinant cells expressing the human α(1A)‐adrenoceptor

BACKGROUND AND PURPOSE: Agonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β‐arrestins. Since the demonstration of biased agonism has implications for drug discovery, it is essential to consider confounding factors contributing to bias. We have examined bias...

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Publicat a:Br J Pharmacol
Autors principals: da Silva Junior, Edilson Dantas, Sato, Masaaki, Merlin, Jon, Broxton, Natalie, Hutchinson, Dana S, Ventura, Sabatino, Evans, Bronwyn A, Summers, Roger J
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481649/
https://ncbi.nlm.nih.gov/pubmed/28444738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13837
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