Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase

Homologous to E6AP C-terminal (HECT) ubiquitin (Ub) ligases (E3s) are a large class of enzymes that bind to their substrates and catalyze ubiquitination through the formation of a Ub thioester intermediate. The mechanisms by which these E3s assemble polyubiquitin chains on their substrates remain po...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: French, Michael E., Klosowiak, Julian L., Aslanian, Aaron, Reed, Steven I., Yates, John R., Hunter, Tony
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481553/
https://ncbi.nlm.nih.gov/pubmed/28461335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789479
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