Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines

Studies indicate that elevated interleukin-6 (IL-6) levels engage IL6Rα-gp130 receptor complexes to activate signal transducer and activator of transcription 3 (STAT3) that is hyperactivated in many cancers including head and neck squamous cell carcinoma (HNSCC). Our previous HCS campaign identified...

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Veröffentlicht in:J Chem Biol
Hauptverfasser: Sen, Malabika, Johnston, Paul A., Pollock, Netanya I., DeGrave, Kara, Joyce, Sonali C., Freilino, Maria L., Hua, Yun, Camarco, Daniel P., Close, David A., Huryn, Donna M., Wipf, Peter, Grandis, Jennifer R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480263/
https://ncbi.nlm.nih.gov/pubmed/28684999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-017-0169-9
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