Polypyrimidine Tract-Binding Protein Enhances the Internal Ribosomal Entry Site-Dependent Translation of p27(Kip1) mRNA and Modulates Transition from G(1) to S Phase

The p27(Kip1) protein plays a critical role in the regulation of cell proliferation through the inhibition of cyclin-dependent kinase activity. Translation of p27(Kip1) is directed by an internal ribosomal entry site (IRES) in the 5′ nontranslated region of p27(Kip1) mRNA. Here, we report that polyp...

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Detalles Bibliográficos
Main Authors: Cho, Sungchan, Kim, Jong Heon, Back, Sung Hoon, Jang, Sung Key
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC548013/
https://ncbi.nlm.nih.gov/pubmed/15684381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.4.1283-1297.2005
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