Polypyrimidine Tract-Binding Protein Enhances the Internal Ribosomal Entry Site-Dependent Translation of p27(Kip1) mRNA and Modulates Transition from G(1) to S Phase

The p27(Kip1) protein plays a critical role in the regulation of cell proliferation through the inhibition of cyclin-dependent kinase activity. Translation of p27(Kip1) is directed by an internal ribosomal entry site (IRES) in the 5′ nontranslated region of p27(Kip1) mRNA. Here, we report that polyp...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Cho, Sungchan, Kim, Jong Heon, Back, Sung Hoon, Jang, Sung Key
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2005
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548013/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15684381/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.25.4.1283-1297.2005
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