Coordinate Regulation of the Mother Centriole Component Nlp by Nek2 and Plk1 Protein Kinases

Mitotic entry requires a major reorganization of the microtubule cytoskeleton. Nlp, a centrosomal protein that binds γ-tubulin, is a G(2)/M target of the Plk1 protein kinase. Here, we show that human Nlp and its Xenopus homologue, X-Nlp, are also phosphorylated by the cell cycle-regulated Nek2 kinas...

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Detalhes bibliográficos
Main Authors: Rapley, Joseph, Baxter, Joanne E., Blot, Joelle, Wattam, Samantha L., Casenghi, Martina, Meraldi, Patrick, Nigg, Erich A., Fry, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC548010/
https://ncbi.nlm.nih.gov/pubmed/15684383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.4.1309-1324.2005
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