Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

Myelin is required for proper nervous system function. Schwann cells in developing nerves depend on extrinsic signals from the axon and from the extracellular matrix to first sort and ensheathe a single axon and then myelinate it. Neuregulin 1 type III (Nrg1III) and laminin α2β1γ1 (Lm211) are the ke...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Ghidinelli, Monica, Poitelon, Yannick, Shin, Yoon Kyoung, Ameroso, Dominique, Williamson, Courtney, Ferri, Cinzia, Pellegatta, Marta, Espino, Kevin, Mogha, Amit, Monk, Kelly, Podini, Paola, Taveggia, Carla, Nave, Klaus-Armin, Wrabetz, Lawrence, Park, Hwan Tae, Feltri, Maria Laura
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479503/
https://ncbi.nlm.nih.gov/pubmed/28636612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2001408
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