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Soluble Neuregulin-1 Has Bifunctional, Concentration-Dependent Effects on Schwann Cell Myelination

Members of the neuregulin-1 (Nrg1) growth factor family play important roles during Schwann cell development. Recently, it has been shown that the membrane-bound type III isoform is required for Schwann cell myelination. Interestingly, however, Nrg1 type II, a soluble isoform, inhibits the process....

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Главные авторы: Syed, Neeraja, Reddy, Kavya, Yang, David P., Taveggia, Carla, Salzer, James L., Maurel, Patrice, Kim, Haesun A.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2870719/
https://ncbi.nlm.nih.gov/pubmed/20427670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1681-09.2010
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