Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

Myelin is required for proper nervous system function. Schwann cells in developing nerves depend on extrinsic signals from the axon and from the extracellular matrix to first sort and ensheathe a single axon and then myelinate it. Neuregulin 1 type III (Nrg1III) and laminin α2β1γ1 (Lm211) are the ke...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Ghidinelli, Monica, Poitelon, Yannick, Shin, Yoon Kyoung, Ameroso, Dominique, Williamson, Courtney, Ferri, Cinzia, Pellegatta, Marta, Espino, Kevin, Mogha, Amit, Monk, Kelly, Podini, Paola, Taveggia, Carla, Nave, Klaus-Armin, Wrabetz, Lawrence, Park, Hwan Tae, Feltri, Maria Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479503/
https://ncbi.nlm.nih.gov/pubmed/28636612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2001408
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