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Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters

Methamphetamine is one of the most abused illicit drugs with roughly 1.2 million users in the United States alone. A large portion of methamphetamine and its metabolites is eliminated by the kidney with renal clearance larger than glomerular filtration clearance. Yet the mechanism of active renal se...

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Détails bibliographiques
Publié dans:Drug Metab Dispos
Auteurs principaux: Wagner, David J., Sager, Jennifer E., Duan, Haichuan, Isoherranen, Nina, Wang, Joanne
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478906/
https://ncbi.nlm.nih.gov/pubmed/28428365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074708
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