Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease

Emerging evidence suggests that pulmonary iron accumulation is implicated in a spectrum of chronic lung diseases. However, the mechanism(s) involved in pulmonary iron deposition and its role in the in vivo pathogenesis of lung diseases remains unknown. Here we show that a point mutation in the murin...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Neves, Joana, Leitz, Dominik, Kraut, Simone, Brandenberger, Christina, Agrawal, Raman, Weissmann, Norbert, Mühlfeld, Christian, Mall, Marcus A., Altamura, Sandro, Muckenthaler, Martina U.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478206/
https://ncbi.nlm.nih.gov/pubmed/28499927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.04.036
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