T-Cell Therapy Using Interleukin-21–Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression

PURPOSE: Peripheral blood–derived antigen-specific cytotoxic T cells (CTLs) provide a readily available source of effector cells that can be administered with minimal toxicity in an outpatient setting. In metastatic melanoma, this approach results in measurable albeit modest clinical responses in pa...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Chapuis, Aude G., Roberts, Ilana M., Thompson, John A., Margolin, Kim A., Bhatia, Shailender, Lee, Sylvia M., Sloan, Heather L., Lai, Ivy P., Farrar, Erik A., Wagener, Felecia, Shibuya, Kendall C., Cao, Jianhong, Wolchok, Jedd D., Greenberg, Philip D., Yee, Cassian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2016
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477923/
https://ncbi.nlm.nih.gov/pubmed/27269940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.65.5142
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