Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient

Adoptive transfer of peripheral blood–derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky tumors. Similarly, monotherapy with anti-CTLA4 infrequently yields sustained remissions in patients with metastatic melanoma. We postulated that a...

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Publicado en:J Exp Med
Autores principales: Chapuis, Aude G., Lee, Sylvia M., Thompson, John A., Roberts, Ilana M., Margolin, Kim A., Bhatia, Shailender, Sloan, Heather L., Lai, Ivy, Wagener, Felecia, Shibuya, Kendall, Cao, Jianhong, Wolchok, Jedd D., Greenberg, Philip D., Yee, Cassian
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2016
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925025/
https://ncbi.nlm.nih.gov/pubmed/27242164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20152021
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