Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient

Adoptive transfer of peripheral blood–derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky tumors. Similarly, monotherapy with anti-CTLA4 infrequently yields sustained remissions in patients with metastatic melanoma. We postulated that a...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Chapuis, Aude G., Lee, Sylvia M., Thompson, John A., Roberts, Ilana M., Margolin, Kim A., Bhatia, Shailender, Sloan, Heather L., Lai, Ivy, Wagener, Felecia, Shibuya, Kendall, Cao, Jianhong, Wolchok, Jedd D., Greenberg, Philip D., Yee, Cassian
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925025/
https://ncbi.nlm.nih.gov/pubmed/27242164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20152021
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