Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I

Merkel cell carcinoma (MCC) is an aggressive skin cancer that typically requires the persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins that can serve as ideal immunotherapeutic targets. Several immune evasion mechanisms are active in MCC including down-regulation of HLA class-I...

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Hauptverfasser: Chapuis, Aude G., Afanasiev, Olga K., Iyer, Jayasri G., Paulson, Kelly G., Parvathaneni, Upendra, Hwang, Joo Ha, Lai, Ivy, Roberts, Ilana M., Sloan, Heather L., Bhatia, Shailender, Shibuya, Kendall C., Gooley, Ted, Desmarais, Cindy, Koelle, David M., Yee, Cassian, Nghiem, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888869/
https://ncbi.nlm.nih.gov/pubmed/24432305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0087
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