Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I

Merkel cell carcinoma (MCC) is an aggressive skin cancer that typically requires the persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins that can serve as ideal immunotherapeutic targets. Several immune evasion mechanisms are active in MCC including down-regulation of HLA class-I...

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Main Authors: Chapuis, Aude G., Afanasiev, Olga K., Iyer, Jayasri G., Paulson, Kelly G., Parvathaneni, Upendra, Hwang, Joo Ha, Lai, Ivy, Roberts, Ilana M., Sloan, Heather L., Bhatia, Shailender, Shibuya, Kendall C., Gooley, Ted, Desmarais, Cindy, Koelle, David M., Yee, Cassian, Nghiem, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888869/
https://ncbi.nlm.nih.gov/pubmed/24432305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0087
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