Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

PURPOSE: Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of patients with advanced GCT exhibit cisplatin resistance, which requires intensive salvage treatment, and have a 50% risk...

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Veröffentlicht in:J Clin Oncol
Hauptverfasser: Bagrodia, Aditya, Lee, Byron H., Lee, William, Cha, Eugene K., Sfakianos, John P., Iyer, Gopa, Pietzak, Eugene J., Gao, Sizhi Paul, Zabor, Emily C., Ostrovnaya, Irina, Kaffenberger, Samuel D., Syed, Aijazuddin, Arcila, Maria E., Chaganti, Raju S., Kundra, Ritika, Eng, Jana, Hreiki, Joseph, Vacic, Vladimir, Arora, Kanika, Oschwald, Dayna M., Berger, Michael F., Bajorin, Dean F., Bains, Manjit S., Schultz, Nikolaus, Reuter, Victor E., Sheinfeld, Joel, Bosl, George J., Al-Ahmadie, Hikmat A., Solit, David B., Feldman, Darren R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477828/
https://ncbi.nlm.nih.gov/pubmed/27646943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.68.7798
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