HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells

[Image: see text] The HIV-1 frameshift-stimulating (FSS) RNA, a regulatory RNA of critical importance in the virus’ life cycle, has been posited as a novel target for anti-HIV drug development. We report the synthesis and evaluation of triazole-containing compounds able to bind the FSS with high aff...

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Pubblicato in:ACS Chem Biol
Autori principali: Hilimire, Thomas A., Chamberlain, Jeffrey M., Anokhina, Viktoriya, Bennett, Ryan P., Swart, Oliver, Myers, Jason R., Ashton, John M., Stewart, Ryan A., Featherston, Aaron L., Gates, Kathleen, Helms, Eric D., Smith, Harold C., Dewhurst, Stephen, Miller, Benjamin L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2017
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477779/
https://ncbi.nlm.nih.gov/pubmed/28448121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00052
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