High-Affinity Recognition of HIV-1 Frameshift-Stimulating RNA Alters Frameshifting in Vitro and Interferes with HIV-1 Infectivity

[Image: see text] The life cycle of the human immunodeficiency virus type 1 (HIV-1) has an absolute requirement for ribosomal frameshifting during protein translation in order to produce the polyprotein precursor of the viral enzymes. While an RNA stem-loop structure (the “HIV-1 Frameshift Stimulati...

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Main Authors: Ofori, Leslie O., Hilimire, Thomas A., Bennett, Ryan P., Brown, Nathaniel W., Smith, Harold C., Miller, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954503/
https://ncbi.nlm.nih.gov/pubmed/24387306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401438g
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