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Strategies for Recognition of Stem-loop RNA Structures by Synthetic Ligands: Application to the HIV-1 Frameshift Stimulatory Sequence
Production of the Gag-Pol polyprotein in human immunodeficiency virus (HIV) requires a -1 ribosomal frameshift, which is directed by a highly conserved RNA stemloop. Building on our discovery of a set of disulfide-containing peptides that bind this RNA, we describe medicinal chemistry efforts design...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928052/ https://ncbi.nlm.nih.gov/pubmed/20672840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100231t |
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