Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot

SARS-CoV-2 uses −1 programmed ribosomal frameshifting (−1 PRF) to control expression of key viral proteins. Because modulating −1 PRF can attenuate the virus, ligands binding to the RNA pseudoknot that stimulates −1 PRF may have therapeutic potential. Mutations in the pseudoknot have occurred during...

Full description

Saved in:
Bibliographic Details
Published in:J Mol Biol
Main Authors: Neupane, Krishna, Munshi, Sneha, Zhao, Meng, Ritchie, Dustin B., Ileperuma, Sandaru M., Woodside, Michael T.
Format: Artigo
Language:Inglês
Published: Elsevier Ltd. 2020
Subjects:
Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483078/
https://ncbi.nlm.nih.gov/pubmed/32920049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.09.006
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items