Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot

SARS-CoV-2 uses −1 programmed ribosomal frameshifting (−1 PRF) to control expression of key viral proteins. Because modulating −1 PRF can attenuate the virus, ligands binding to the RNA pseudoknot that stimulates −1 PRF may have therapeutic potential. Mutations in the pseudoknot have occurred during...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Biol
Prif Awduron: Neupane, Krishna, Munshi, Sneha, Zhao, Meng, Ritchie, Dustin B., Ileperuma, Sandaru M., Woodside, Michael T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Ltd. 2020
Pynciau:
Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483078/
https://ncbi.nlm.nih.gov/pubmed/32920049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.09.006
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