HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells

[Image: see text] The HIV-1 frameshift-stimulating (FSS) RNA, a regulatory RNA of critical importance in the virus’ life cycle, has been posited as a novel target for anti-HIV drug development. We report the synthesis and evaluation of triazole-containing compounds able to bind the FSS with high aff...

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發表在:ACS Chem Biol
Main Authors: Hilimire, Thomas A., Chamberlain, Jeffrey M., Anokhina, Viktoriya, Bennett, Ryan P., Swart, Oliver, Myers, Jason R., Ashton, John M., Stewart, Ryan A., Featherston, Aaron L., Gates, Kathleen, Helms, Eric D., Smith, Harold C., Dewhurst, Stephen, Miller, Benjamin L.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2017
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477779/
https://ncbi.nlm.nih.gov/pubmed/28448121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00052
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