Development of a selective inhibitor of Protein Arginine Deiminase 2

Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the biological roles of this isozyme and may ulti...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Muth, Aaron, Subramanian, Venkataraman, Beaumont, Edward, Nagar, Mitesh, Kerry, Philip, McEwan, Paul, Srinath, Hema, Clancy, Kathleen, Parelkar, Sangram, Thompson, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477668/
https://ncbi.nlm.nih.gov/pubmed/28328217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00274
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