Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells

Imatinib is actively transported by organic cation transporter-1 (OCT-1) influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia blood mononuclear cells is significantly associated with poor molecular response to imatinib. Herein we report that, in diagnostic chronic myeloi...

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Pubblicato in:Haematologica
Autori principali: Wang, Jueqiong, Lu, Liu, Kok, Chung H., Saunders, Verity A., Goyne, Jarrad M., Dang, Phuong, Leclercq, Tamara M., Hughes, Timothy P., White, Deborah L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477603/
https://ncbi.nlm.nih.gov/pubmed/28154092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.153270
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