Contrasting effects of diclofenac and ibuprofen on active imatinib uptake into leukaemic cells

BACKGROUND: The human organic cation transporter-1 (OCT-1) is the primary active protein for imatinib uptake into target BCR-ABL-positive cells. Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used by chronic myeloid leukaemia (CML) patients on imatinib to manage musculoskeletal compla...

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Hlavní autoři: Wang, J, Hughes, T P, Kok, C H, Saunders, V A, Frede, A, Groot-Obbink, K, Osborn, M, Somogyi, A A, D'Andrea, R J, White, D L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364120/
https://ncbi.nlm.nih.gov/pubmed/22531634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.173
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