Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells

Imatinib is actively transported by organic cation transporter-1 (OCT-1) influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia blood mononuclear cells is significantly associated with poor molecular response to imatinib. Herein we report that, in diagnostic chronic myeloi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Haematologica
Prif Awduron: Wang, Jueqiong, Lu, Liu, Kok, Chung H., Saunders, Verity A., Goyne, Jarrad M., Dang, Phuong, Leclercq, Tamara M., Hughes, Timothy P., White, Deborah L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ferrata Storti Foundation 2017
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477603/
https://ncbi.nlm.nih.gov/pubmed/28154092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.153270
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