Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage

Spermidine, a natural polyamine presented widely in mammalian cells, has been implicated to extend the lifespan of several model organisms by inducing autophagy. However, the effect of spermidine against neuronal damage has not yet been fully determined. In this study, neuronal cell injury was induc...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Main Authors: Yang, Yi, Chen, Sicong, Zhang, Yuqing, Lin, Xiaoxia, Song, Yiyin, Xue, Zhaoliang, Qian, Haoran, Wang, Shanshan, Wan, Guihua, Zheng, Xiaoxiang, Zhang, Lihui
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477584/
https://ncbi.nlm.nih.gov/pubmed/28383560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.161
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