EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression. Genome-wide associated studies have implicated EZH2 in the control of height and mutations in EZH2...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Lui, Julian C., Garrison, Presley, Nguyen, Quang, Ad, Michal, Keembiyehetty, Chithra, Chen, Weiping, Jee, Youn Hee, Landman, Ellie, Nilsson, Ola, Barnes, Kevin M., Baron, Jeffrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477487/
https://ncbi.nlm.nih.gov/pubmed/27897169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13685
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