EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression. Genome-wide associated studies have implicated EZH2 in the control of height and mutations in EZH2...

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Pubblicato in:Nat Commun
Autori principali: Lui, Julian C., Garrison, Presley, Nguyen, Quang, Ad, Michal, Keembiyehetty, Chithra, Chen, Weiping, Jee, Youn Hee, Landman, Ellie, Nilsson, Ola, Barnes, Kevin M., Baron, Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477487/
https://ncbi.nlm.nih.gov/pubmed/27897169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13685
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