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Total Chemical Synthesis of Biologically Active Fluorescent Dye-Labeled Ts1 Toxin()
Ts1 toxin is a protein found in the venom of the Brazilian scorpion Tityus serrulatus. Ts1 binds to the domain II voltage sensor in the voltage-gated sodium channel Nav and modifies its voltage dependence. In the work reported here, we established an efficient total chemical synthesis of the Ts1 pro...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5477175/ https://ncbi.nlm.nih.gov/pubmed/24989851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201404438 |
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