ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction

Estrogen-related receptor α (ERRα) is a member of the nuclear receptor superfamily controlling energy homeostasis; however, its precise role in regulating antiviral innate immunity remains to be clarified. Here, we showed that ERRα deficiency conferred resistance to viral infection both in vivo and...

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Udgivet i:PLoS Pathog
Main Authors: He, Xiang, Ma, Shengli, Tian, Yinyin, Wei, Congwen, Zhu, Yongjie, Li, Feng, Zhang, Pingping, Wang, Penghao, Zhang, Yanhong, Zhong, Hui
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476288/
https://ncbi.nlm.nih.gov/pubmed/28591144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006347
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