128. Dysregulation of Kynurenine Metabolism is Related to Proinflammatory Cytokines, Prefrontal Cortex Volume, and Attention in Schizophrenia

Background: The kynurenine pathway (KP) of tryptophan (TRP) catabolism is considered to link the immune and neurotransmitter systems. The KP metabolite kynurenic acid (KYNA) shows increases in the brain of patients with schizophrenia. Here, we tested whether changes in brain KP enzyme mRNAs and plas...

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Publicado en:Schizophr Bull
Main Authors: Weickert, Thomas, Kindler, Jochen, Zavitsanou, Katerina, Lim, Chai, Guillemin, Gilles, Galletly, Cherrie, Liu, Dennis, Balzan, Ryan, Boerrigter, Danny, Bruggemann, Jason, O’Donnell, Maryanne, Lenroot, Rhoshel, Weickert, Cynthia Shannon
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475646/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbx021.186
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