128. Dysregulation of Kynurenine Metabolism is Related to Proinflammatory Cytokines, Prefrontal Cortex Volume, and Attention in Schizophrenia

Background: The kynurenine pathway (KP) of tryptophan (TRP) catabolism is considered to link the immune and neurotransmitter systems. The KP metabolite kynurenic acid (KYNA) shows increases in the brain of patients with schizophrenia. Here, we tested whether changes in brain KP enzyme mRNAs and plas...

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發表在:Schizophr Bull
Main Authors: Weickert, Thomas, Kindler, Jochen, Zavitsanou, Katerina, Lim, Chai, Guillemin, Gilles, Galletly, Cherrie, Liu, Dennis, Balzan, Ryan, Boerrigter, Danny, Bruggemann, Jason, O’Donnell, Maryanne, Lenroot, Rhoshel, Weickert, Cynthia Shannon
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475646/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbx021.186
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