Short DNA Hairpins Compromise Recombinant Adeno-Associated Virus Genome Homogeneity

Short hairpin (sh)RNAs delivered by recombinant adeno-associated viruses (rAAVs) are valuable tools to study gene function in vivo and a promising gene therapy platform. Our data show that incorporation of shRNA transgenes into rAAV constructs reduces vector yield and produces a population of trunca...

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Vydáno v:Mol Ther
Hlavní autoři: Xie, Jun, Mao, Qin, Tai, Phillip W.L., He, Ran, Ai, Jianzhong, Su, Qin, Zhu, Ye, Ma, Hong, Li, Jia, Gong, Shoufang, Wang, Dan, Gao, Zhen, Li, Mengxin, Zhong, Li, Zhou, Heather, Gao, Guangping
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474962/
https://ncbi.nlm.nih.gov/pubmed/28462820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.03.028
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