Effective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold

Short hairpin RNAs that are delivered by recombinant adeno-associated virus (rAAV) have the potential to elicit long-term RNAi therapy for human disease. However, the discovery that short hairpin sequences can cause truncation of the rAAV genome calls into question the efficiency and gene-silencing...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Xie, Jun, Tai, Phillip W.L., Brown, Alexander, Gong, Shoufang, Zhu, Sha, Wang, Yi, Li, Chengjian, Colpan, Cansu, Su, Qin, He, Ran, Ma, Hong, Li, Jia, Ye, Hanqing, Ko, Jihye, Zamore, Phillip D., Gao, Guangping
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
Soggetti:
Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001000/
https://ncbi.nlm.nih.gov/pubmed/31843447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.018
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi