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DNA Internal Motion Likely Accelerates Protein Target Search in a Packed Nucleoid
Transcription factors must diffuse through densely packed and coiled DNA to find their binding sites. Using a coarse-grained model of DNA and lac repressor (LacI) in the Escherichia coli nucleoid, simulations were performed to examine how LacI diffuses in such a space. Despite the canonical picture...
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| Veröffentlicht in: | Biophys J |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474843/ https://ncbi.nlm.nih.gov/pubmed/28591599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.049 |
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