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Structural basis for ligand binding to an enzyme by a conformational selection pathway
Proteins can bind target molecules through either induced fit or conformational selection pathways. In the conformational selection model, a protein samples a scarcely populated high-energy state that resembles a target-bound conformation. In enzymatic catalysis, such high-energy states have been id...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474765/ https://ncbi.nlm.nih.gov/pubmed/28559350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700919114 |
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