Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria

Infection by the human bacterial pathogen Listeria monocytogenes is mainly controlled by the positive regulatory factor A (PrfA), a member of the Crp/Fnr family of transcriptional activators. Published data suggest that PrfA requires the binding of a cofactor for full activity, and it was recently p...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hall, Michael, Grundström, Christin, Begum, Afshan, Lindberg, Mikael J., Sauer, Uwe H., Almqvist, Fredrik, Johansson, Jörgen, Sauer-Eriksson, A. Elisabeth
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187702/
https://ncbi.nlm.nih.gov/pubmed/27930316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614028114
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